Adrenal glands: Importants drugs

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1. Aldosterone and Fludrocortisone (Florinef)

These are mineralocorticoids. They areused clinically in steroid replacement therapy (e.g., Addison disease).

2. Spironolactone

It is an aldosterone receptor antagonist. It is used clinically to treat primary hyperaldosteronism (e.g., Conn syndrome).

3. Cortisol, Cortisone, and Corticosteroid

These are glucocorticoids. They are used clinically in steroid replacement therapy (e.g., Addison disease).

4. Methylprednisolone (Medrol) and Prednisone (Deltasone)

These are glucocorticoids. They are used clinically as anti-inflammatory agents, as immunosuppressive agents, and in chemotherapy (prednisone is part of the MOPP regimen).

5. Dexamethasone (Decadron)

It is a glucocorticoid. It is used clinically as an anti inflammatory agent, as an immunosuppressive agent to suppress ACTH secretion, and in the diagnosis of Cushing disease (dexamethasone suppression test).

6. Aminoglutethimide (Cytadren)

It inhibits desmolase, thereby preventing synthesis of cortisol. It is used clinically to treat breast cancer and Cushing syndrome.

7. Metyrapone (Metopirone)

It inhibits 11-hydroxylase, thereby preventing synthesis of cortisol. It is used clinically to treat Cushing syndrome.

8. Ketoconazole

It inhibits the cytochrome P450 enzymes, thereby preventing steroid biosynthesis in general. It is used clinically to treat Cushing syndrome.

9. Mitotane (Lysodren)

It destroys the cells of the zona fasciculata and zona reticularis. It is used clinically to treat adrenocortical carcinoma

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