Most common lymph node affected – cervical lymph node.
( 2 types on the basis of Reed Sternberg cells)
—(following 4 subtypes)
■ Best / most specific marker for RS cells —- PAX-5 (>90%…latest info) > CD 30 (80 to 100% of classical HL). Other markers CD 15 ( 75-85% ).
2) NODULAR SCLEROSIS
• Most common HL (world)
• Mediastinal involvement most common in this HL.
• Male and female are equally affected ( other HL, males are more commonly affected)
• Lacunar reed Sternberg cells are seen (cytoplasmic lacuna formed due to tissue fixation artefact )
• “Collagen Bands” are forming nodules in Lymph nodes.
2) MIXED CELLULARITY
• Most common HL in India
• Maximum RS cells are seen.
3) LYMPHOCYTE DEPLETED
• Least common type of HL
• RS cells (various names) —pleomorphic / Mummified / necrobiotic
• Worst prognosis
4) LYMPHOCYTE RICH
• Minimum RS cells are seen. B) LYMPHOCYTE PREDOMINANT
• Popcorn RS cells (or lympho – histiocytic (L&H ) RS cells )
• Immunophenotyping- CD 20 (=BCL6+ve), CD 45, CD 79a, EMA (Epithelial Membrane Antigen)
• Best prognosis amongst all HL. #HIGH yield info about HL:-
• EBV and HIV infections ,both are most commonly a/w(amongst Hodgkins lymphoma subtype)—-MIXED CELLULARITY (HODGKINS LYMPHOMA)
• HIV associated Hodgkins Lymphomas are —- mixed cellularity (most common) nodular sclerosis and lymphocyte depleted • EBV not associated with HL— 1) Nodular sclerosis 2) lymphocyte predominant