Hodgkin’s lymphoma
HODGKIN’S LYMPHOMA
Most common lymph node affected – cervical lymph node.
WHO classification ( 2 types on the basis of Reed Sternberg cells)
A) CLASSICAL—(following 4 subtypes) ■ Best / most specific marker for RS cells —- PAX-5 (>90%…latest info) > CD 30 (80 to 100% of classical HL). Other markers CD 15 ( 75-85% ).
1) NODULAR SCLEROSIS. • Most common HL (world) • Mediastinal involvement most common in this HL. • Male and female are equally affected ( other HL, males are more commonly affected) • Lacunar reed Sternberg cells are seen (cytoplasmic lacuna formed due to tissue fixation artefact ) • “Collagen Bands” are forming nodules in Lymph nodes.
2) MIXED CELLULARITY • Most common HL in India • Maximum RS cells are seen.
3) LYMPHOCYTE DEPLETED. • Least common type of HL • RS cells (various names) —pleomorphic / Mummified / necrobiotic • Worst prognosis
4) LYMPHOCYTE RICH • Minimum RS cells are seen. B) LYMPHOCYTE PREDOMINANT • Popcorn RS cells (or lympho – histiocytic (L&H ) RS cells ) • Immunophenotyping- CD 20 (=BCL6+ve), CD 45, CD 79a, EMA (Epithelial Membrane Antigen) • Best prognosis amongst all HL. #HIGH yield info about HL:- • EBV and HIV infections ,both are most commonly a/w(amongst Hodgkins lymphoma subtype)—-
MIXED CELLULARITY (HODGKINS LYMPHOMA) • HIV associated Hodgkins Lymphomas are —- mixed cellularity (most common) nodular sclerosis and lymphocyte depleted • EBV not associated with HL— 1) Nodular sclerosis 2) lymphocyte predominant
Most common lymph node affected – cervical lymph node.
WHO classification ( 2 types on the basis of Reed Sternberg cells)
A) CLASSICAL—(following 4 subtypes) ■ Best / most specific marker for RS cells —- PAX-5 (>90%…latest info) > CD 30 (80 to 100% of classical HL). Other markers CD 15 ( 75-85% ).
1) NODULAR SCLEROSIS. • Most common HL (world) • Mediastinal involvement most common in this HL. • Male and female are equally affected ( other HL, males are more commonly affected) • Lacunar reed Sternberg cells are seen (cytoplasmic lacuna formed due to tissue fixation artefact ) • “Collagen Bands” are forming nodules in Lymph nodes.
2) MIXED CELLULARITY • Most common HL in India • Maximum RS cells are seen.
3) LYMPHOCYTE DEPLETED. • Least common type of HL • RS cells (various names) —pleomorphic / Mummified / necrobiotic • Worst prognosis
4) LYMPHOCYTE RICH • Minimum RS cells are seen. B) LYMPHOCYTE PREDOMINANT • Popcorn RS cells (or lympho – histiocytic (L&H ) RS cells ) • Immunophenotyping- CD 20 (=BCL6+ve), CD 45, CD 79a, EMA (Epithelial Membrane Antigen) • Best prognosis amongst all HL. #HIGH yield info about HL:- • EBV and HIV infections ,both are most commonly a/w(amongst Hodgkins lymphoma subtype)—-
MIXED CELLULARITY (HODGKINS LYMPHOMA) • HIV associated Hodgkins Lymphomas are —- mixed cellularity (most common) nodular sclerosis and lymphocyte depleted • EBV not associated with HL— 1) Nodular sclerosis 2) lymphocyte predominant
Aniket Oswal
Aniket has completed M.D Internal Medicine from Bharati Vidyapeeth Medical College. In his free time he enjoys traveling, music, surfing internet and blogging. He also happens to be founder of PgAspirant.in, LooneyLaughs.com
